Structure of PDB 7kkq Chain B

Receptor sequence
>7kkqB (length=203) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILLDLAPEDKEYQSVEEEMQSTIREAGGIFNRYNVIRIQKVVNKKLRE
RFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGA
GIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSF
LQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQI
MKP
3D structure
PDB7kkq Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
ChainB
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 78P B H1184 G1185 Y1213 F1214 A1215 K1220 S1221 Y1224 I1228 E1291 H74 G75 Y103 F104 A105 K110 S111 Y114 I118 E181 BindingDB: IC50=10715nM
BS02 ZN B C1234 H1237 C1242 C1245 C124 H127 C132 C135
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7kkq, PDBe:7kkq, PDBj:7kkq
PDBsum7kkq
PubMed33361107
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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