Structure of PDB 7kko Chain B

Receptor sequence
>7kkoB (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]
SQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQK
VVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHA
YIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFC
RVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYP
EYLITYQIMKPE
3D structure
PDB7kko Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
ChainB
Resolution1.56 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1234 H1237 C1242 C1245 C132 H135 C140 C143
BS02 09L B H1184 G1185 F1188 I1192 H1201 Y1203 I1212 Y1213 F1214 S1221 Y1224 E1291 H82 G83 F86 I90 H99 Y101 I110 Y111 F112 S119 Y122 E189 BindingDB: IC50=1230nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7kko, PDBe:7kko, PDBj:7kko
PDBsum7kko
PubMed33361107
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

[Back to BioLiP]