Structure of PDB 7kja Chain B

Receptor sequence
>7kjaB (length=349) Species: 9606 (Homo sapiens) [Search protein sequence]
DPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSKKEV
PVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMII
TEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLA
ARNILVNSNLVCKVSDFGPIRWTAPEAISYRKFTSASDVWSFGIVMWEVM
TYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARR
PKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSPFRTVSEWLESI
KMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGL
3D structure
PDB7kja Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker.
ChainB
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D739 A741 R743 N744 D757 P780
Catalytic site (residue number reindexed from 1) D148 A150 R152 N153 D166 P169
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP B I619 E623 V627 A644 K646 M695 L746 I30 E34 V38 A53 K55 M104 L155
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7kja, PDBe:7kja, PDBj:7kja
PDBsum7kja
PubMed34857764
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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