Structure of PDB 7kho Chain B

Receptor sequence
>7khoB (length=432) Species: 1042876 (Pseudomonas putida S16) [Search protein sequence]
GFDYDVVVVGGGFAGATAARECGLQGYRTLLLEARSRLGGRTFTSRFAGQ
EIEFGGAWVHWLQPHVWAEMQRYGLGVVEDPLTNLDKTLIMYNDGSVESI
SPDEFGKNIRIAFEKLCHDAWEVFPRPHEPMFTERARELDKSSVLDRIKT
LGLSRLQQAQINSYMALYAGETTDKFGLPGVLKLFACGGWNYDAFMDTET
HYRIQGGTIGLINAMLTDSGAEVRMSVPVTAVEQVNGGVKIKTDDDEIIT
AGVVVMTVPLNTYKHIGFTPALSKGKQRFIKEGQLSKGAKLYVHVKQNLG
RVFAFADEQQPLNWVQTHDYSDELGTILSITIARKETIDVNDRDAVTREV
QKMFPGVEVLGTAAYDWTADPFSLGAWAAYGVGQLSRLKDLQAAEGRILF
AGAETSNGWHAVIDGAVESGLRAGREVKQLLS
3D structure
PDB7kho Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2.
ChainB
Resolution2.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.4.2.2: nicotine dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NCT B L217 Y218 W364 W427 L167 Y168 W314 W377
BS02 FAD B V59 G60 G62 A64 E83 A84 R85 G90 R91 G105 G106 W108 V279 V308 P309 F422 W427 G452 A453 V462 I463 A466 V9 G10 G12 A14 E33 A34 R35 G40 R41 G55 G56 W58 V229 V258 P259 F372 W377 G402 A403 V412 I413 A416
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:7kho, PDBe:7kho, PDBj:7kho
PDBsum7kho
PubMed33464876
UniProtF8G0P2|NICA2_PSEP6 Nicotine dehydrogenase (Gene Name=nicA2)

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