Structure of PDB 7khk Chain B

Receptor sequence
>7khkB (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
NYSYIDPTQLPYDHKWEFPRNRLSFGKTLGGKVVEATAQGLIKSDAAMTV
AVKMLKSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCC
YGDLLNFLDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT
KICDFGLARVIKSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIF
LWELFSLGSSPYPGMPVDSKFYKMIKEGFRHAPAEMYDIMKTCWDADPDK
RPTFKQIVQDIEKQIS
3D structure
PDB7khk Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
ChainB
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WEJ B L595 A621 K623 E640 T670 E671 Y672 C673 C674 Y675 G676 L799 C809 D810 L29 A51 K53 E66 T96 E97 Y98 C99 C100 Y101 G102 L143 C153 D154
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7khk, PDBe:7khk, PDBj:7khk
PDBsum7khk
PubMed34236401
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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