Structure of PDB 7khj Chain B

Receptor sequence
>7khjB (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
IDPTQLPYDHKWEFPRNRLSFGKTLGGKVVEATAQGLIKSDAAMTVAVKM
LKPSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGD
LLNFLDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTITKICDFG
LARVISNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSL
GSSPYPGMPVDSKFYKMIKEGFREHAPAEMYDIMKTCWDADPDKRPTFKQ
IVQDIEKQISE
3D structure
PDB7khj Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WEG B L595 Y672 C673 C674 Y675 G676 L799 C809 L25 Y95 C96 C97 Y98 G99 L140 C147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7khj, PDBe:7khj, PDBj:7khj
PDBsum7khj
PubMed34236401
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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