Structure of PDB 7kev Chain B

Receptor sequence
>7kevB (length=471) Species: 9606 (Homo sapiens) [Search protein sequence]
SIPWNLERITPPRYRSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEED
ASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLE
FIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFR
DDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDII
GASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFS
AKDVINEAWFPEDQRVLTPNLVAALPPSQLFCRTVWSAHSGPTRMATAIA
RCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAGEGVYAIARCC
LLPQANCSVHTAPPTRVHCHQQGHVLTGCSSHWEVEDQPNQCVGHEASIH
ASCCHAPGLECKVKEHGIQEQVTVACEEGWTLTGCSALPGTSHVLGAYAV
DNTCVVRSRAVTAVAICCRSR
3D structure
PDB7kev Identification of a PCSK9-LDLR disruptor peptide with in vivo function.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N317 F318 V346 L348 L351 G352 T353 E366 Q382 S383 G384 N148 F149 V177 L179 L182 G183 T184 E197 Q213 S214 G215
BS02 CA B T335 C358 D360 T166 C189 D191
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7kev, PDBe:7kev, PDBj:7kev
PDBsum7kev
PubMed34547225
UniProtQ8NBP7|PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (Gene Name=PCSK9)

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