Structure of PDB 7kcl Chain B

Receptor sequence
>7kclB (length=614) Species: 9606 (Homo sapiens) [Search protein sequence]
PLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISN
ASDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELV
SNLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYS
RSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEAR
VRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVGEWQHEEFYRYVA
QAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSRSSVALYSRKVLI
QTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRL
IKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYES
SALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDT
EVLFCFEQFDELTLLHLREFDKKKLISVETDIVVDHCLSEKETEELMAWM
RNVLGSRVTNVKVTLRLDTHPAMVTVLEMGAARHFLRMQTQEERAQLLQP
TLEINPRHALIKKLNQLRASEPGLAQLLVDQIYENAMIAAGLVDDPRAMV
GRLNELLVKALERH
3D structure
PDB7kcl Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates
ChainB
Resolution3.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B M352 F353 H538 H620 M283 F284 H466 H534
BS02 ANP B N119 A123 D158 M163 N171 S178 G179 G199 Q200 F201 G202 V203 G204 F205 T251 R402 N50 A54 D89 M94 N102 S109 G110 G130 Q131 F132 G133 V134 G135 F136 T182 R330
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0019901 protein kinase binding
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0009386 translational attenuation
GO:0060255 regulation of macromolecule metabolic process
GO:0061077 chaperone-mediated protein folding
GO:1901856 negative regulation of cellular respiration
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0016020 membrane
GO:0071944 cell periphery

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kcl, PDBe:7kcl, PDBj:7kcl
PDBsum7kcl
PubMed
UniProtQ12931|TRAP1_HUMAN Heat shock protein 75 kDa, mitochondrial (Gene Name=TRAP1)

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