Structure of PDB 7k72 Chain B

Receptor sequence
>7k72B (length=317) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
APEVLRQWQALAEEVREHQFRYYVRDAPIISDAEFDELLRRLEALEEQHP
ELRTPDSPTQLVGGAGFATDFEPVDHLERMLSLDNAFTADELAAWAGRIH
AEVGDAAHYLCELKIDGVALSLVYREGRLTRASTRGDGRTGEDVTLNART
IADVPERLTPGDDYPVPEVLEVRGEVFFRLDDFQALNASLVEEGKAPFAN
PRNSAAGSLRQKDPAVTARRRLRMICHGLGHVEGFRPATLHQAYLALRAW
GLPVSEHTTLATDLAGVRERIDYWGEHRHEVDHEIDGVVVKVDEVALQRR
LGSTSRAPRWAIAYKYP
3D structure
PDB7k72 Structure of DNA ligase A from Mycobacterium tuberculosis bound to NAD
ChainB
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.5.1.2: DNA ligase (NAD(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD B H27 Y31 Y32 P37 I39 D41 F44 D45 S91 L92 E121 K123 I124 R144 E184 H236 K300 K324 H18 Y22 Y23 P28 I30 D32 F35 D36 S82 L83 E112 K114 I115 R135 E175 H227 K291 K315
BS02 CA B Q28 Y32 F44 Q19 Y23 F35
Gene Ontology
Molecular Function
GO:0003911 DNA ligase (NAD+) activity

View graph for
Molecular Function
External links
PDB RCSB:7k72, PDBe:7k72, PDBj:7k72
PDBsum7k72
PubMed
UniProtP9WNV1|DNLJ_MYCTU DNA ligase A (Gene Name=ligA)

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