Structure of PDB 7k1h Chain B

Receptor sequence
>7k1hB (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREA
TSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLD
YVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGRVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG
IPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIE
FSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMD
3D structure
PDB7k1h Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
ChainB
Resolution2.602 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VNS B V726 A743 I744 K745 E749 I759 M766 C775 R776 L777 L788 T790 D855 F856 R858 V26 A43 I44 K45 E49 I59 M66 C75 R76 L77 L88 T90 D155 F156 R158
BS02 YY3 B L718 G719 V726 L792 M793 G796 C797 L844 D855 L18 G19 V26 L92 M93 G96 C97 L144 D155 BindingDB: IC50=2.0nM,Ki=14nM,EC50=6.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7k1h, PDBe:7k1h, PDBj:7k1h
PDBsum7k1h
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

[Back to BioLiP]