Structure of PDB 7k0l Chain B

Receptor sequence
>7k0lB (length=492) Species: 9606 (Homo sapiens) [Search protein sequence]
GLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHA
TEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQ
SHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAG
VCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGK
GCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPR
TRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGAL
GPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHS
HSAVYATSLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRR
LKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATP
IIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRL
3D structure
PDB7k0l Structural insights into the regulation of human serine palmitoyltransferase complexes.
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.50: serine C-palmitoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B G238 H263 E315 A346 H347 T376 T378 K379 G186 H211 E263 A294 H295 T324 T326 K327
BS02 VRP B Y122 W134 Y176 H263 S319 H347 K379 G497 P499 Y70 W82 Y124 H211 S267 H295 K327 G445 P447 BindingDB: IC50=0.130000nM
Gene Ontology
Molecular Function
GO:0004758 serine C-palmitoyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006686 sphingomyelin biosynthetic process
GO:0009058 biosynthetic process
GO:0030148 sphingolipid biosynthetic process
GO:0046511 sphinganine biosynthetic process
GO:0046512 sphingosine biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:0060612 adipose tissue development
GO:1904504 positive regulation of lipophagy
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0017059 serine palmitoyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7k0l, PDBe:7k0l, PDBj:7k0l
PDBsum7k0l
PubMed33558761
UniProtO15270|SPTC2_HUMAN Serine palmitoyltransferase 2 (Gene Name=SPTLC2)

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