Structure of PDB 7jxw Chain B

Receptor sequence
>7jxwB (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE
ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLL
DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ
HVKITDFGLAPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD
GIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELII
EFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM
3D structure
PDB7jxw Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YY3 B L718 G719 V726 A743 L792 M793 P794 G796 C797 R841 L844 D855 L19 G20 V27 A44 L93 M94 P95 G97 C98 R142 L145 D156 BindingDB: IC50=2.0nM,Ki=14nM,EC50=6.0nM
BS02 VNS B V726 A743 I744 K745 A755 E758 I759 M766 R776 L777 L788 M790 D855 F856 L858 V27 A44 I45 K46 A56 E59 I60 M67 R77 L78 L89 M91 D156 F157 L159
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7jxw, PDBe:7jxw, PDBj:7jxw
PDBsum7jxw
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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