Structure of PDB 7jxm Chain B

Receptor sequence
>7jxmB (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREA
TSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLD
YVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGLAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD
GIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELII
EFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVD
3D structure
PDB7jxm Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
ChainB
Resolution2.192 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YY3 B L718 G719 V726 A743 M793 G796 C797 D800 L18 G19 V26 A43 M93 G96 C97 D100 BindingDB: IC50=2.0nM,Ki=14nM,EC50=6.0nM
BS02 9LL B V726 A743 K745 I759 C775 R776 L777 L788 M790 D855 F856 L858 V26 A43 K45 I59 C75 R76 L77 L88 M90 D155 F156 L158 BindingDB: IC50=3.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7jxm, PDBe:7jxm, PDBj:7jxm
PDBsum7jxm
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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