Structure of PDB 7jvn Chain B

Receptor sequence
>7jvnB (length=470) Species: 9606 (Homo sapiens) [Search protein sequence]
RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTH
IKIQNTGDYYDLYGGEKFATLAELVQYYMEQLKIELKYPLNCADPTSERW
FHGHLSGKEAEKLLTEKGKHGSFLVREPGDFVLSVRTSKVTHVMIRCQEL
KYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIE
SRVRELSKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFD
HTRVVLHVSDYINANIIMPKSYIATQGCLQNTVNDFWRMVFQENSRVIVM
TTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSK
VGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPV
VVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMV
QTEAQYRFIYMAVQHYIETL
3D structure
PDB7jvn Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
ChainB
Resolution1.917 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VKP B R111 F113 T219 E249 E250 T253 L254 Q257 P491 K492 Q495 R99 F101 T192 E213 E214 T217 L218 Q221 P436 K437 Q440 MOAD: ic50=0.029uM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7jvn, PDBe:7jvn, PDBj:7jvn
PDBsum7jvn
PubMed32910655
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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