Structure of PDB 7juq Chain B

Receptor sequence
>7juqB (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
TSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWGEVAIRLIDIERDNED
QLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVR
DAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVIT
DFGLFSISGVLQREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHS
DVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISD
ILLFCWAFEQEERPTFTKLMDMLEKLP
3D structure
PDB7juq Structural basis for the action of the drug trametinib at KSR-bound MEK.
ChainB
Resolution3.22 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D786 K788 K790 N791 D803 Q825
Catalytic site (residue number reindexed from 1) D134 K136 K138 N139 D151 Q170
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B I672 V680 R692 L741 C742 K788 N791 F793 D803 I21 V29 R40 L89 C90 K136 N139 F141 D151
BS02 MG B N791 D803 N139 D151
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7juq, PDBe:7juq, PDBj:7juq
PDBsum7juq
PubMed32927473
UniProtQ6VAB6|KSR2_HUMAN Kinase suppressor of Ras 2 (Gene Name=KSR2)

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