Structure of PDB 7jup Chain B

Receptor sequence
>7jupB (length=557) Species: 9606 (Homo sapiens) [Search protein sequence]
SPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKV
VQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDED
GNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVL
TIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTE
DKSCRDYYIEYNFKYLQCLTALNAMVQNNRIELLNHPVCKEYLLMKWLAY
GFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINNSYLIKTCMIL
VFLSSIFGYCKEISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY
FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYI
LLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQ
LVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLKRIAMQVELHTSLEKKL
PLWFLRKVDQKSTIVYPSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQK
MEIISET
3D structure
PDB7jup Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
ChainB
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VKM B L707 L708 W711 Q851 R852 E854 I858 A971 R975 Q979 H983 L243 L244 W247 Q361 R362 E364 I368 A481 R485 Q489 H493 BindingDB: IC50=5.60nM
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jup, PDBe:7jup, PDBj:7jup
PDBsum7jup
PubMed33749283
UniProtO75762|TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 (Gene Name=TRPA1)

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