Structure of PDB 7juo Chain B

Receptor sequence
>7juoB (length=113) Species: 9606 (Homo sapiens) [Search protein sequence]
IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPM
DLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAE
VFEQEIDPVMQSL
3D structure
PDB7juo XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YF2 B L1119 L1120 L36 L37 BindingDB: Kd=<1.000000nM
BS02 YF2 B P1110 Q1113 P1114 V1115 L1120 N1168 R1173 V1174 P27 Q30 P31 V32 L37 N85 R90 V91 BindingDB: Kd=<1.000000nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7juo, PDBe:7juo, PDBj:7juo
PDBsum7juo
PubMed35064087
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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