Structure of PDB 7ju5 Chain B

Receptor sequence
>7ju5B (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
KILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKM
LKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKY
GSLRGFLRESRKVGPGYLGDERALTMGDLISFAWQISQGMQYLAEMKLVH
RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIES
LFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER
PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKR
3D structure
PDB7ju5 Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D874 A876 R878 N879 D892
Catalytic site (residue number reindexed from 1) D152 A154 R156 N157 D170
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q4J B L730 G731 E732 G733 G736 K737 A756 M759 E805 Y806 A807 G810 L881 L21 G22 E23 G24 G27 K28 A47 M50 E96 Y97 A98 G101 L159 BindingDB: IC50=6000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ju5, PDBe:7ju5, PDBj:7ju5
PDBsum7ju5
PubMed33161056
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

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