Structure of PDB 7jm6 Chain B

Receptor sequence

>7jm6B (length=667) Species: 9031 (Gallus gallus)

LSLKYESLDYDNSENQLFLEEERRINHAAFRTVEIKRWVICAMIGILTGL
VACFIDIVVENLAGLKYRVVKDNIDKFTEKGGLSFSLLLWATLNASVVMV
GSVIVAFIEPVAAGSGIPQIKCYLNGVKIPHVVRLKTLVIKVCGVILSVV
GGLAVGKEGPMIHSGAVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFV
SAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLN
SVLSVYHGNAWDLSSPGLINFGRFDSEKMGYTIQEIPIFIFMGVVGGILG
ALFNALNYWLTMFRIRYIHRPCLQVIEAMLVAAVTAAVGFVMIYCSRAFF
NTPEKSVVNLFHDPPGSYNPMTLGMFTLMYFFLACWTYGLTVSAGVFIPS
LLIGAAWGRLFGISLSYLSKGSIWADPGKYALMGAAAQLGGIVRMTLSLT
VIMMEATGNVTYGFPIMLVLMTAKIVGDYFVEGLYDMHIQLQSVPFLHWE
APVTSHSLTAREVMSTPVTCLRRIERVGTVVDILSDTSSNHNGFPVVESN
PNTTQVAGLRGLILRSQLIVLLKHKVFVERRLKLKDFRDAYPRFPPIQSI
HVSQDERECMIDLSEFMNPSPYTVPREASLPRVFKLFRALGLRHLVVVNN
HNEVVGMVTRKDLARYR

3D structure

• PDB: 7jm6 Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1.
• Chain: B
• Resolution: 2.92 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	B	E90 S91 S627 V630 T631 N652 H653 N654 R763 T779 D782	E6 S7 S515 V518 T519 N540 H541 N542 R643 T659 D662
BS02	CL	B	S199 G507 V508	S115 G395 V396
BS03	CL	B	G240 E242 G507 F509 I510	G156 E158 G395 F397 I398
BS04	CL	B	G198 G200 Q203	G114 G116 Q119
BS05	0J1	B	M127 V217 R218 L219 I252 A254 R260 S261 T262 S263 R713	M43 V133 R134 L135 I168 A170 R176 S177 T178 S179 R593

Gene Ontology

Molecular Function

• GO:0005247 voltage-gated chloride channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0006821 chloride transport
• GO:0055085 transmembrane transport
• GO:1902476 chloride transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7jm6, PDBe:7jm6, PDBj:7jm6
• PDBsum: 7jm6
• PubMed: 32749217
• UniProt: Q5ZL60