Structure of PDB 7jl8 Chain B

Receptor sequence
>7jl8B (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
PPSIWRLFHRQAQAFNFVKSCKEDVHVFALECKVGDGQRIYLVTTYAEFW
FYYKSRKNLLHCYEVIPENAVCKLYFDLEFNKPANPGADGKKMVALLIEY
VCKALQELYGVNCSAEDVLNLDSSTDEKFSRHLIFQLHDVAFKDNIHVGN
FLRKILQPALDLLDLSFLVVKNNMGEKHLFVDLGVYTRNRNFRLYKSSKI
GKRVALEVTEDNKFFPIQSKDVSDEYQYFLSSLVSNVRFSDTLRILTCEP
3D structure
PDB7jl8 Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R47 Q48 G74 Q75 R76 Y78 T285 R286 R10 Q11 G37 Q38 R39 Y41 T187 R188
BS02 dna B D280 R288 D182 R190
BS03 DTP B R76 Y100 D114 E116 K165 S167 R288 N289 R291 K297 R39 Y63 D77 E79 K128 S130 R190 N191 R193 K199
BS04 CA B D114 E116 D77 E79
BS05 CA B D114 E116 D280 D77 E79 D182
Gene Ontology
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0042276 error-prone translesion synthesis

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Molecular Function
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Biological Process
External links
PDB RCSB:7jl8, PDBe:7jl8, PDBj:7jl8
PDBsum7jl8
PubMed34188055
UniProtQ96LW4|PRIPO_HUMAN DNA-directed primase/polymerase protein (Gene Name=PRIMPOL)

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