Structure of PDB 7jk1 Chain B

Receptor sequence
>7jk1B (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
EPPSIWRLFHRQAQAFNFVKSCKEDVHVFALECKVGDGQRIYLVTTYAEF
WFYYKSRKNLLHCYEVIPENAVCKLYFDLEFNKPANPGADGKKMVALLIE
YVCKALQELYGVNCSAEDVLNLDSSTDEKFSRHLIFQLHDVAFKDNIHVG
NFLRKILQPALDLLPDLSFLVVKNNMGEKHLFVDLGVYTRNRNFRLYKSS
KIGKRVALEVTEDNKFFPIQSKDVSDEYQYFLSSLVSNVRFSDTLRILTC
EP
3D structure
PDB7jk1 Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
ChainB
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B H46 R47 Q48 G74 R76 Y78 T285 R286 H10 R11 Q12 G38 R40 Y42 T189 R190
BS02 DCP B Y100 D114 K165 S167 H169 R288 N289 F290 R291 K297 Y64 D78 K129 S131 H133 R192 N193 F194 R195 K201
BS03 CA B D114 E116 D78 E80
Gene Ontology
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0042276 error-prone translesion synthesis

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Molecular Function
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Biological Process
External links
PDB RCSB:7jk1, PDBe:7jk1, PDBj:7jk1
PDBsum7jk1
PubMed34188055
UniProtQ96LW4|PRIPO_HUMAN DNA-directed primase/polymerase protein (Gene Name=PRIMPOL)

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