Structure of PDB 7jhx Chain B

Receptor sequence

>7jhxB (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]

KFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLV
PSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEE
DYFLYVAYSDESVYGK

3D structure

PDB

7jhx Insights on autophagosome-lysosome tethering from structural and biochemical characterization of human autophagy factor EPG5.

Chain

Resolution

1.91 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	Y25 R28 P30 K46 K48 Y49 L50 P52 F60 R67 F104	Y24 R27 P29 K45 K47 Y48 L49 P51 F59 R66 F103

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008429	phosphatidylethanolamine binding
GO:0030957	Tat protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0048487	beta-tubulin binding
GO:0050811	GABA receptor binding

	Biological Process
GO:0000045	autophagosome assembly
GO:0000422	autophagy of mitochondrion
GO:0006914	autophagy
GO:0006995	cellular response to nitrogen starvation
GO:0061723	glycophagy
GO:0097352	autophagosome maturation

	Cellular Component
GO:0000421	autophagosome membrane
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005776	autophagosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle

External links

PDB	RCSB:7jhx, PDBe:7jhx, PDBj:7jhx
PDBsum	7jhx
PubMed	33674710
UniProt	Q9H0R8\|GBRL1_HUMAN Gamma-aminobutyric acid receptor-associated protein-like 1 (Gene Name=GABARAPL1)