Structure of PDB 7jhd Chain B

Receptor sequence
>7jhdB (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDSEASMMGLLTNLADRELVHMINWA
KRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLD
RNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTK
DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGM
EHLYSMKCKPLSDLLLEMLDAHR
3D structure
PDB7jhd Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer.
ChainB
Resolution2.402 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 V376 L539 E542 M543 I47 V65 L214 E217 M218
BS02 V9J B L346 A350 E353 L384 M388 L391 M421 I424 H524 L525 L35 A39 E42 L73 M77 L80 M110 I113 H202 L203 BindingDB: EC50=0.800000nM
External links
PDB RCSB:7jhd, PDBe:7jhd, PDBj:7jhd
PDBsum7jhd
PubMed33177154
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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