Structure of PDB 7fug Chain B

Receptor sequence
>7fugB (length=338) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
EHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKENPLSQFLEGE
ILSASKMLSKFRKIIKEEINDIKDTDVIMKRKVTLLISEKISVDITLALE
SKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKEETWRLSFSHIEK
EILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFS
SYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYF
IPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
3D structure
PDB7fug Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainB
Resolution2.106 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H390 C396 C397 C404 H206 C212 C213 C220
BS02 YP8 B R376 F379 S380 Y436 F443 N482 Y483 F484 F488 R192 F195 S196 Y252 F259 N298 Y299 F300 F304
External links
PDB RCSB:7fug, PDBe:7fug, PDBj:7fug
PDBsum7fug
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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