Structure of PDB 7fu5 Chain B

Receptor sequence
>7fu5B (length=354) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKENPLSQ
FLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISE
KISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHA
KEGQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLL
EQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNC
VTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFP
VFDE
3D structure
PDB7fu5 Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainB
Resolution2.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H390 C397 C404 H223 C230 C237
BS02 YMO B R376 L377 F379 S380 Y436 F443 N482 F484 I485 F488 L490 R209 L210 F212 S213 Y269 F276 N315 F317 I318 F321 L323
External links
PDB RCSB:7fu5, PDBe:7fu5, PDBj:7fu5
PDBsum7fu5
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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