Structure of PDB 7ftz Chain B

Receptor sequence
>7ftzB (length=351) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKENPLSQ
FLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISE
KISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHA
KQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQ
LKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVT
YFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVF
D
3D structure
PDB7ftz Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H390 C404 H221 C235
BS02 YQQ B A247 K362 R376 L377 S378 F379 E383 Y436 N482 F484 I485 F488 A87 K198 R207 L208 S209 F210 E214 Y267 N313 F315 I316 F319
External links
PDB RCSB:7ftz, PDBe:7ftz, PDBj:7ftz
PDBsum7ftz
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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