Structure of PDB 7ftt Chain B

Receptor sequence
>7fttB (length=348) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKENPLSQ
FLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISE
KISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHE
ETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKE
RFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFL
QCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFD
3D structure
PDB7ftt Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainB
Resolution2.235 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H390 C396 C397 C404 H218 C224 C225 C232
BS02 YPU B R376 L377 S378 F379 Y436 F443 N482 F484 R204 L205 S206 F207 Y264 F271 N310 F312
External links
PDB RCSB:7ftt, PDBe:7ftt, PDBj:7ftt
PDBsum7ftt
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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