Structure of PDB 7fsb Chain B

Receptor sequence
>7fsbB (length=436) Species: 9606 (Homo sapiens) [Search protein sequence]
RADVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSI
IATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVES
FAGSPLSYRPVAIALDTKGPGSGPGLSEQDVRDLRFGVEHGVDIVFASFV
RKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARG
DLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAET
SDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLF
EELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYR
PRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIE
SGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
3D structure
PDB7fsb Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
ChainB
Resolution2.495 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FBP B T444 T445 T446 S449 W494 R501 G526 R528 P529 G530 S531 G532 Y533 T337 T338 T339 S342 W387 R394 G419 R421 P422 G423 S424 G425 Y426
BS02 OXL B K282 E284 A305 G307 D308 T340 K175 E177 A198 G200 D201 T233
BS03 MG B E284 D308 E177 D201
BS04 OE0 B F38 L39 Q405 L406 E409 F29 L30 Q298 L299 E302
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0030955 potassium ion binding
Biological Process
GO:0006096 glycolytic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7fsb, PDBe:7fsb, PDBj:7fsb
PDBsum7fsb
PubMed36753880
UniProtP30613|KPYR_HUMAN Pyruvate kinase PKLR (Gene Name=PKLR)

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