Structure of PDB 7fh3 Chain B

Receptor sequence
>7fh3B (length=391) Species: 9606 (Homo sapiens) [Search protein sequence]
SDIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGF
MREKEYLQVMHFDTLLDDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHG
GRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDL
QVLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALL
MQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVL
DPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPE
TKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARHN
EFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLE
3D structure
PDB7fh3 Structural basis for the substrate recognition mechanism of ATP-sulfurylase domain of human PAPS synthase 2.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.25: adenylyl-sulfate kinase.
2.7.7.4: sulfate adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 B S303 A304 G363 D364 S82 A83 G142 D143
BS02 SO4 B Q409 R411 A515 Q188 R190 A294
BS03 SO4 B N416 A597 N195 A376
BS04 SO4 B K315 R329 K94 R108
BS05 SO4 B H418 R512 H197 R291
BS06 BGC B G446 W447 T448 P454 L455 G225 W226 T227 P233 L234
Gene Ontology
Molecular Function
GO:0004781 sulfate adenylyltransferase (ATP) activity
Biological Process
GO:0000103 sulfate assimilation

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Molecular Function
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Biological Process
External links
PDB RCSB:7fh3, PDBe:7fh3, PDBj:7fh3
PDBsum7fh3
PubMed34818583
UniProtO95340|PAPS2_HUMAN Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (Gene Name=PAPSS2)

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