Structure of PDB 7f8g Chain B

Receptor sequence
>7f8gB (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
NEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFN
LADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSGVDWMRK
LAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSL
KALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTG
KESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEAL
RHALELEYL
3D structure
PDB7f8g Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase.
ChainB
Resolution3.491 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1RI B T278 F282 Y294 M308 W410 R414 L420 T421 D422 W424 L425 T14 F18 Y30 M44 W131 R135 L141 T142 D143 W145 L146
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0007275 multicellular organism development

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Molecular Function
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Biological Process
External links
PDB RCSB:7f8g, PDBe:7f8g, PDBj:7f8g
PDBsum7f8g
PubMed34761455
UniProtO00167|EYA2_HUMAN Eyes absent homolog 2 (Gene Name=EYA2)

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