Structure of PDB 7f43 Chain B

Receptor sequence
>7f43B (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
HHNLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERI
QNAFLWQSYQVKKRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSC
AGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVVRVLTGVFTKG
RAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFTA
3D structure
PDB7f43 PARP15 catalytic domain in complex with Niraparib
ChainB
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3JD B H559 G560 C578 G580 N582 A583 V584 Y591 Y598 S599 Y604 H81 G82 C100 G102 N104 A105 V106 Y113 Y120 S121 Y126
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

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Molecular Function
External links
PDB RCSB:7f43, PDBe:7f43, PDBj:7f43
PDBsum7f43
PubMed
UniProtQ460N3|PAR15_HUMAN Protein mono-ADP-ribosyltransferase PARP15 (Gene Name=PARP15)

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