Structure of PDB 7f2l Chain B

Receptor sequence
>7f2lB (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]
LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDT
LITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEIL
AAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLL
QEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKK
VTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFF
RQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPD
AQDILDTLEDNREWYQSTIP
3D structure
PDB7f2l Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety.
ChainB
Resolution2.10111 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H164 H200 D201 D318 H73 H109 D110 D227
BS02 1AS B Y159 H160 H164 M273 D318 W332 T333 I336 M357 Q369 G371 F372 Y68 H69 H73 M182 D227 W241 T242 I245 M266 Q278 G280 F281
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7f2l, PDBe:7f2l, PDBj:7f2l
PDBsum7f2l
PubMed34520193
UniProtQ08499|PDE4D_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4D (Gene Name=PDE4D)

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