Structure of PDB 7ezt Chain B

Receptor sequence
>7eztB (length=727) Species: 349741 (Akkermansia muciniphila ATCC BAA-835) [Search protein sequence]
SIPPVKAGAKQLPMPSVSGAQIKLLGADYEQLVNSKGKIAPVISDTPVNV
SFKVTKDGKEAVSKDYEIMLQAPQAAQGNPKPRIIPEILQWKGGQGEYKL
GNTVTIACPDKELGKLFAADMEDVLGKKVKLVAPGAKADISLSLLKGGNL
GREGYRLQIARDGVRLGAAAPTGLFWGTRTLLQMLRQTPGSVPCGTAVDF
PRYQLRGFMLDVARTPYPLSYLKDVIRTMAWYKMNDLHLVINNNYIFHEH
YVDNGHDPFKESYAAFRLESKMKGKDGTPLTARDLFYTKKEFADLVSYAR
KYGVNIVPEFDTPGHALSFTRLRPDLIYKGPMNHEKRRCEMLDAANPETI
DLVSKVFDEYMLKDPKLGRPVFADCGVVHVGADEFYGDKEDYRHFANAVL
THALKRGYTPRIWGSLSAKPGKTPVVSKGVQMNLWSTGWMKAWEAVNQGY
DVINTNDGALYIVPFAGYYRMDRNHKGLYNNWIPNRIGNETLPSGHPQLL
GGTFAVWNDETDIMHTGYAPYDIWGIISGSMDVLSQKLWGTAKAPDTFEQ
HRELVSSIGNAPRTNPLHKWKDSQPLTVKPSSLPQKLDKPALGPNYRLTM
ELELTAAPEGKEQVLLAAPEGELLAVMKDGTVGFRRDDSLEFSFGAKLPV
GKKVKVEIVGEPEKTSLLLDGEPAGTAVLKNFSDKSKDFSDKFKHRPKVH
RSTFILPLKELGSSFQGKVFHMNVQPL
3D structure
PDB7ezt Nucleotide binding as an allosteric regulatory mechanism for Akkermansia muciniphila beta- N -acetylhexosaminidase Am2136.
ChainB
Resolution2.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.52: beta-N-acetylhexosaminidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B Y327 R592 Y298 R563
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004563 beta-N-acetylhexosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0000272 polysaccharide catabolic process
GO:0005975 carbohydrate metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7ezt, PDBe:7ezt, PDBj:7ezt
PDBsum7ezt
PubMed36394293
UniProtB2UPR7|H2136_AKKM8 Beta-hexosaminidase Amuc_2136 (Gene Name=Amuc_2136)

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