Structure of PDB 7ew9 Chain B

Receptor sequence
>7ew9B (length=169) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKE
3D structure
PDB7ew9 KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge.
ChainB
Resolution2.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 05C B D12 A59 G60 E62 Y64 D69 M72 D92 H95 Y96 Q99 I100 V103 D13 A60 G61 E63 Y65 D70 M73 D93 H96 Y97 Q100 I101 V104
BS02 GDP B G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 S145 G14 V15 G16 K17 S18 A19 F29 D31 N117 K118 D120 S146
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7ew9, PDBe:7ew9, PDBj:7ew9
PDBsum7ew9
PubMed35075146
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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