Structure of PDB 7eix Chain B

Receptor sequence
>7eixB (length=464) Species: 9606 (Homo sapiens) [Search protein sequence]
SMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPED
PDSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAIN
CLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPSSQGGGVLQSTV
SESTLIALLAARKNKILEMKTSEPDADESSLNARLVAYASDQAHSSVEKA
GLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGV
CAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFT
FNPSKWMMVHFDCTGFWVKDKYKLQQTFSVTDFMHWQIPLSRRFRSVKLW
FVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRL
KGPNSLTENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRD
WNLIRDAATLILSQ
3D structure
PDB7eix Structural analysis of the HDC Y334F mutant
ChainB
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 4.1.1.22: histidine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B Y81 T149 V150 S151 H194 D273 A275 N302 K305 Y81 T149 V150 S151 H194 D273 A275 N302 K305
Gene Ontology
Molecular Function
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0019752 carboxylic acid metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7eix, PDBe:7eix, PDBj:7eix
PDBsum7eix
PubMed
UniProtP19113|DCHS_HUMAN Histidine decarboxylase (Gene Name=HDC)

[Back to BioLiP]