Structure of PDB 7egh Chain B

Receptor sequence
>7eghB (length=963) Species: 9606 (Homo sapiens) [Search protein sequence]
GFESPRPYKLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSK
QCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVD
PDAGNGELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEG
SMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNG
DLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHF
CLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAA
YASMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFISRMSWSDEW
VLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTGGVLLHPIF
NPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENRISMEFMLQVFNK
LLSLASTASSQKFQSHMWSQMLVSTSGFLKSISNVSGKDIQPLIKQWVDQ
SGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSF
NHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVDMDLSAMDADSPL
LWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVVAQQESILALEKFPTP
ASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTR
MFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFI
LDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPD
VRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQKNGHVPSDPALFK
SYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQNDPVPYVRHK
ILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTSHDWRLRCGAVDLY
FTLFGLSRPSCLP
3D structure
PDB7egh Structural insights into preinitiation complex assembly on core promoters.
ChainB
Resolution3.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B K540 R541 K515 R516
BS02 dna B S594 K595 S569 K570
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006282 regulation of DNA repair
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0014070 response to organic cyclic compound
GO:0042789 mRNA transcription by RNA polymerase II
GO:0045893 positive regulation of DNA-templated transcription
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0033276 transcription factor TFTC complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7egh, PDBe:7egh, PDBj:7egh
PDBsum7egh
PubMed33795473
UniProtQ6P1X5|TAF2_HUMAN Transcription initiation factor TFIID subunit 2 (Gene Name=TAF2)

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