Structure of PDB 7eg0 Chain B

Receptor sequence
>7eg0B (length=567) Species: 9606 (Homo sapiens) [Search protein sequence]
NISVDLETNYAELVLDVGRVTLGENSRKKMKDCKLRKKQNESVSRAMCAL
LNSGGGVIKAEIENEDYSYTKDGIGLDLENSFSNILLFVPEYLDFMQNGN
YFLIFVKSWSLNTSGLRITTLSSNLYKRDITSAKVMNATAALEFLKDMKK
TRGRLYLRPELLAKRPCVDIQEENNMKALAGVFFDRTELDRKEKLTFTES
THVEIKNFSTERLLQRIKEILPQYVSAFANTDGGYLFIGLNEDKEIIGFK
AEMSDLDDLEREIEKSIRKMPVHHFCMEKKKINYSCKFLGVYDKGSLCGY
VCALRVERFCCAVFAKEPDSWHVKDNRVMQLTRKEWIQFMVEAEPKFSSA
YEEVISQINTSLPAPHSWPLLEWQRQRHHCPGLSGRITYTPENLCRKLFL
QHEGLKQLICEEMSSVRKGSLIFSRSWSVDLGLQENHKVLCDALLISQDS
PPVLYTFHMVQDEEFKGYSTQTALTLKQKLAKIGGYTKKVCVMTKIFYLS
PEGMTSCQYDLRSQVIYPESYYFTRRKYLLKALFKALKRLKSLRDQFSFA
ENLYQIIGIDCFQKNDK
3D structure
PDB7eg0 Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells.
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H275 C312 H274 C311
Gene Ontology
Molecular Function
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0043022 ribosome binding
Biological Process
GO:0016075 rRNA catabolic process
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7eg0, PDBe:7eg0, PDBj:7eg0
PDBsum7eg0
PubMed34707099
UniProtQ8IYM2|SLN12_HUMAN Ribonuclease SLFN12 (Gene Name=SLFN12)

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