Structure of PDB 7ed5 Chain B

Receptor sequence
>7ed5B (length=150) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
NVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLF
TMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTC
DGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRAN
3D structure
PDB7ed5 A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
ChainB
Resolution2.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B N43 K46 N1 K4
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008242 omega peptidase activity
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:7ed5, PDBe:7ed5, PDBj:7ed5
PDBsum7ed5
PubMed35110538
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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