Structure of PDB 7e6t Chain B

Receptor sequence
>7e6tB (length=793) Species: 9606 (Homo sapiens) [Search protein sequence]
PDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWL
QAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKID
SLNFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLL
SNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIE
KFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGP
DLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKA
GQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLRPLCTGDENISSVE
TPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKV
EAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVF
KEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGII
EGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEF
LSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLL
FSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLV
FEANLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEG
SLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVW
ISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIIL
3D structure
PDB7e6t Structural insights into the activation of human calcium-sensing receptor.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B S170 I187 P188 S146 I163 P164
BS02 CA B T100 T145 T79 T121
BS03 TCR B R66 S147 A168 S170 Y218 E297 R45 S123 A144 S146 Y194 E273
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7e6t, PDBe:7e6t, PDBj:7e6t
PDBsum7e6t
PubMed34467854
UniProtP41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)

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