Structure of PDB 7e5a Chain B

Receptor sequence
>7e5aB (length=471) Species: 9606 (Homo sapiens) [Search protein sequence]
IHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYL
MNKLAGKNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDV
EKADNKNDIQIFALALLLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKA
RNSPDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPDEYLENSLRPKQGS
DQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEPEF
VQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCI
ENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHATSER
EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLK
DIFGPLEEAVKQGIYSKPNLFIQKTEELKAKYYREPRKGIQAEEVLQKYL
KSKESVSHAILQTDQALTETE
3D structure
PDB7e5a Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP B R48 T49 G50 K51 S52 Y53 V67 A68 S69 R181 D182 P239 L245 L248 R44 T45 G46 K47 S48 Y49 V63 A64 S65 R171 D172 P229 L235 L238
BS02 AF3 B Y47 R48 K51 T75 G100 Y43 R44 K47 T71 G96
BS03 MG B S52 T75 S48 T71
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:7e5a, PDBe:7e5a, PDBj:7e5a
PDBsum7e5a
PubMed33876762
UniProtQ96PP8|GBP5_HUMAN Guanylate-binding protein 5 (Gene Name=GBP5)

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