Structure of PDB 7e4t Chain B

Receptor sequence

>7e4tB (length=664) Species: 9606 (Homo sapiens)

RIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCM
DPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLL
SYQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECV
SSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSK
VENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDLAKLKVAI
KYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPML
SIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQDLHVQGPP
PTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLAT
ISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTA
NSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDE
PNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEF
VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMS
YFDEGGTLPPPFNIISLIQNQHYQEVIRNLVKRYVAAMIRNTEENFKELK
QDISSFRYEVLDLL

3D structure

• PDB: 7e4t Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
• Chain: B
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Y01	B	Y316 F364 F497 A499 N500	Y272 F320 F448 A450 N451
BS02	ZN	B	H172 C176 C178 C181	H140 C144 C146 C149
BS03	CA	B	E418 N436 D439	E369 N387 D390
BS04	YZY	B	Y524 F576 W577	Y475 F527 W528
BS05	Y01	B	F522 L526	F473 L477

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005262 calcium channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7e4t, PDBe:7e4t, PDBj:7e4t
• PDBsum: 7e4t
• PubMed: 33683200
• UniProt: Q9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 (Gene Name=TRPC5)