Structure of PDB 7dua Chain B

Receptor sequence
>7duaB (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
GPLSLSVDAFKIPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGY
TTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESLTMGDLISFAWQISQGMQYLAEMKLVHRDLAAR
NILVAEGRKMKISDFGLSRDVQGRIPVKWMAIESLFDHIYTTQSDVWSFG
VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCW
KQEPDKRPVFADISKDLEKMMVKR
3D structure
PDB7dua Selective RET inhibitor TAS0953/HM06
ChainB
Resolution1.64 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HJ0 B L730 G731 V738 A756 K758 E775 A807 S811 L881 D892 L28 G29 V36 A54 K56 E73 A105 S109 L153 D164 BindingDB: IC50=0.170nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7dua, PDBe:7dua, PDBj:7dua
PDBsum7dua
PubMed
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

[Back to BioLiP]