Structure of PDB 7du9 Chain B

Receptor sequence
>7du9B (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
GPLSLSVDAFKPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYT
TVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESLTMGDLISFAWQISQGMQYLAEMKLVHRDLAARN
ILVAEGRKMKISDFGLSRDVQGRIPVKWMAIESLFDHIYTTQSDVWSFGV
LLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWK
QEPDKRPVFADISKDLEKMMVKR
3D structure
PDB7du9 Selective RET inhibitor TAS0953/HM06
ChainB
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q4J B L730 G731 E732 G733 G736 K737 V738 A756 M759 E805 Y806 A807 G810 L881 L27 G28 E29 G30 G33 K34 V35 A53 M56 E102 Y103 A104 G107 L152 BindingDB: IC50=6000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7du9, PDBe:7du9, PDBj:7du9
PDBsum7du9
PubMed
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

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