Structure of PDB 7dsf Chain B

Receptor sequence
>7dsfB (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
GLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAE
LGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGS
LGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVV
NISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDT
DMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSG
AHVDFYD
3D structure
PDB7dsf The Crystal Structure of human SPR from Biortus.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP B G14 S16 R17 G18 A41 R42 N43 D69 L70 N100 L126 I155 Y170 K174 P198 P200 L201 T203 D204 M205 G11 S13 R14 G15 A38 R39 N40 D66 L67 N97 L123 I152 Y167 K171 P195 P197 L198 T200 D201 M202
BS02 ZN B D257 D260 D254 D257
Gene Ontology
Molecular Function
GO:0004033 aldo-keto reductase (NADPH) activity
GO:0004757 sepiapterin reductase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0006809 nitric oxide biosynthetic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dsf, PDBe:7dsf, PDBj:7dsf
PDBsum7dsf
PubMed
UniProtP35270|SPRE_HUMAN Sepiapterin reductase (Gene Name=SPR)

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