Structure of PDB 7drt Chain B

Receptor sequence
>7drtB (length=496) Species: 9606 (Homo sapiens) [Search protein sequence]
GAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIAPGPTTAVSYMSVKCVD
ARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHME
MSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMA
HERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLP
VNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWY
WRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDI
RQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIF
DMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQ
VFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIV
SQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKN
3D structure
PDB7drt Cryo-EM structure of human Wntless in complex with Wnt3a.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR B P243 P283 W286 F287 P241 P281 W284 F285
BS02 LPE B R261 A272 R259 A270
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
Biological Process
GO:0001707 mesoderm formation
GO:0006886 intracellular protein transport
GO:0009948 anterior/posterior axis specification
GO:0016055 Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0031017 exocrine pancreas development
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0061355 Wnt protein secretion
GO:0061357 positive regulation of Wnt protein secretion
GO:0071529 cementum mineralization
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0030666 endocytic vesicle membrane
GO:0031090 organelle membrane
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7drt, PDBe:7drt, PDBj:7drt
PDBsum7drt
PubMed34315898
UniProtQ5T9L3|WLS_HUMAN Protein wntless homolog (Gene Name=WLS)

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