Structure of PDB 7dpi Chain B

Receptor sequence
>7dpiB (length=536) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
ISVYEDDLFEKLGEEIIEEKLLDVCFDFGLEVDDIEYKNDKKIYKIEVPA
NRYDLICVEGLCRALKNFMCKFDDIKDRRGYVVCCVLKNMNINDSVYNNI
IEIQEKLHHNLGKKRSIHDYDKIKKINFIPLNEKTNLNGMNLIDFYSKNL
NLKPYLKIILSLPPIINCDHTKISLNTKNVFIECTAIDRNKAQIALNILC
SMLSEYCVPKYSIQSFVVIYENQDFSDDQNLIFENKSLTCNIDYVRKLSG
ISHITVHEVNNLLKRMMLSCDIMDNNTFKVTIPFYRSDIMHCCDIIEDIA
IAYGYGNIKYEPCKKHSLNNCSELFRNVLVECGYTEVMTNALLSRDENYN
CMLRTHKSYDDPNINLDEYNPLAAPIQIKNSKTSEYEIIRTSLIVNLLKF
VSANKHRELPLRFFEIGDVSYATYNQTDTNAVNKKYLSIIFSDKFTAGLE
ELHGVLEAILKEYQLFSDYKIEEKKKENDMYYKLIPKEDPSFLNERIVDI
VLHNLKFGVLGIIHPKVLENFSLDIPVSAIEINVET
3D structure
PDB7dpi Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development.
ChainB
Resolution3.597 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D364 E367 D294 E297
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0009328 phenylalanine-tRNA ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dpi, PDBe:7dpi, PDBj:7dpi
PDBsum7dpi
PubMed35460612
UniProtQ8IIW2

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