Structure of PDB 7db8 Chain B

Receptor sequence
>7db8B (length=835) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
MRLPYSWLREVVAVGASGWDVTPGELEQTLLRIGHEVEEVIPLGPVDGPV
TVGRVADIEELTGYKKPIRACAVDIGDRQYREIICGATNFAVGDLVVVAL
PGATLPGGFTISARKAYGRNSDGMICSAAELNLGADHSGILVLPPGAAEP
GADGAGVLGLDDVVFHLAITPDRGYCMSVRGLARELACAYDLDFVDPASN
SRVPPLPIEGPAWPLTVQPETGVRRFALRPVIGIDPAAVSPWWLQRRLLL
CGIRATCPAVDVTNYVMLELGHPMHAHDRNRISGTLGVRFARSGETAVTL
DGIERKLDTADVLIVDDAATAAIGGVMGAASTEVRADSTDVLLEAAIWDP
AAVSRTQRRLHLPSEAARRYERTVDPAISVAALDRCARLLADIAGGEVSP
TLTDWRGDPPCDDWSPPPIRMGVDVPDRIAGVAYPQGTTARRLAQIGAVV
THDGDTLTVTPPSWRPDLRQPADLVEEVLRLEGLEVIPSVLPPAPAGRGL
TAGQQRRRTIGRSLALSGYVEILPTPFLPAGVFDLWGLEADDSRRMTTRV
LNPLEADRPQLATTLLPALLEALVRNVSRGLVDVALFAIAQVVQPTEQTR
GVGLIPVDRRPTDDEIAMLDASLPRQPQHVAAVLAGLREPRGPWGPGRPV
EAADAFEAVRIIARASRVDVTLRPAQYLPWHPGRCAQVFVGESSVGHAGQ
LHPAVIERSGLPKGTCAVELNLDAIPCSAPLPAPRVSPYPAVFQDVSLVV
AADIPAQAVADAVRAGAGDLLEDIALFDVFTGPQIGEHRKSLTFALRFRA
PDRTLTEDDASAARDAAVQSAAERVGAVLRGWKLA
3D structure
PDB7db8 Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .
ChainB
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 B D172 D467 D473 E476 D172 D467 D473 E476
BS02 SO4 B G503 R507 G503 R507
BS03 SO4 B M1 I169 R372 M1 I169 R372
BS04 SO4 B R9 A13 S17 G18 R9 A13 S17 G18
BS05 SO4 B A297 A319 T320 A297 A319 T320
BS06 SO4 B Y739 R803 T804 Y739 R803 T804
BS07 SO4 B H275 G325 M327 E344 W348 H275 G325 M327 E344 W348
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall
GO:0009328 phenylalanine-tRNA ligase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7db8, PDBe:7db8, PDBj:7db8
PDBsum7db8
PubMed33397709
UniProtP9WFU1|SYFB_MYCTU Phenylalanine--tRNA ligase beta subunit (Gene Name=pheT)

[Back to BioLiP]