Structure of PDB 7d7l Chain B

Receptor sequence
>7d7lB (length=312) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
TIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGK
TFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTS
IKWADNNSYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILA
YCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVE
AVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYEL
KHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDV
FYKENSYTTTIK
3D structure
PDB7d7l High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors.
ChainB
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C189 C192 C224 C226 C186 C189 C221 C223
BS02 GXU B P247 P248 Y264 N267 Y268 Y273 P244 P245 Y261 N264 Y265 Y270 BindingDB: IC50=13600nM
BS03 GXU B F69 E70 H73 F66 E67 H70 BindingDB: IC50=13600nM
BS04 GXU B C192 Q195 T225 C226 C189 Q192 T222 C223 BindingDB: IC50=13600nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7d7l, PDBe:7d7l, PDBj:7d7l
PDBsum7d7l
PubMed33864621
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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