Structure of PDB 7d56 Chain B

Receptor sequence
>7d56B (length=635) Species: 9606 (Homo sapiens) [Search protein sequence]
MSLQRIVRVSLEHPTSAVCVAGVETLVDIYGSVPEGTEMFEVYGTPGVDI
YISPNMERGRERADTRRWRFDATLEIIVVMNSPSNDLNDSHVQISYHSSH
EPLPLAYAVLYLTCVDISLDCDLNVDKRQWVWGPSGYGGILLVNCDRDDV
QDNCDQHVHCLQDLEDMSVMVLRTQGPAALFDDHKLVLHTSSYDAKRAQV
FHICGPEDVCEAYRHVLGQDKVSYEVPRLHGDEERFFVEGLSFPDAGFTG
LISFHVTLLDDSASPIFTDTVVFRVAPWIMTPSTLPPLEVYVCRVRNNTC
FVDAVAELARKAGCKLTICPQARWIQDEMELGYVQAPHKTLPVVFDSPRN
GELQDFPYKRILGPDFGYVTREPRSVSGLDSFGNLEVSPPVVANGKEYPL
GRILIGGNLPGSRRVTQVVRDFLHAQKVQPPVELFVDWLAVGHVDEFLSF
VPAPDGKGFRMLLASPGACFKLFQEKQKCGHGRALLFQGVVDDVKTISIN
QVLSNKDLINYNKFVQSCIDWNREVLKRELGLAECDIIDIPQLFKTERKK
ATAFFPDLVNMLVLGKHLGIPKPFGPIINGCCCLEEKVRSLLEPLGLHCT
FIDDFTPYHMLHGEVHCGTNVCRKPFSFKWWNMVP
3D structure
PDB7d56 Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design.
ChainB
Resolution3.175 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.5.3.15: protein-arginine deiminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BFB B W347 D350 H470 L640 H641 C646 W324 D327 H443 L611 H612 C617
BS02 CA B Q349 E353 F407 L410 E411 Q326 E330 F382 L385 E386
BS03 CA B N153 D155 D157 D165 D176 D179 N144 D146 D148 D152 D163 D166
BS04 CA B D157 D179 D388 D148 D166 D365
BS05 CA B E351 D369 S370 N373 E328 D346 S347 N350
BS06 CA B D165 D168 D152 D155
Gene Ontology
Molecular Function
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:7d56, PDBe:7d56, PDBj:7d56
PDBsum7d56
PubMed33971157
UniProtQ9ULW8|PADI3_HUMAN Protein-arginine deiminase type-3 (Gene Name=PADI3)

[Back to BioLiP]