Structure of PDB 7d4k Chain B

Receptor sequence

>7d4kB (length=440) Species: 439493 (Candidatus Pelagibacter sp. HTCC7211)

SKVAIIGAGPCGLSILRAFEHLEKKGEKIPEIVCFEKQESWGGLWNYNWR
TGSDQYGDPVPNSMYRYLWSNGPKECLEFADYSFDQHFGKSIPSFPPREV
LQDYILGRVSKGNIKNKIKFNTRVINTVYRNDKFEINYQDKVNDKTLSDT
FDYLVVSTGHFSVPFIPEYEGMSSFPGRIMHSHDFRDAEEFRGKNVIVLG
SSYSAEDVALQCNKYGAKSVTIGYRHNPMGFKWPKGMKEVHYLDKLDGKK
AIFKDGTEQDADVVILCTGYLHHFPFLDESLKLKTHNRLYPPKLYKGVVW
QDNHKLLYLGMQDQFHTFNMFDCQAWFARDVIMDKIKMPSDDEIDKDINK
WVSMEEKLENPDQMIDFQTEYTKELHNISDYPKIDFELIRKHFKEWEHHK
VEDILTYRNKSFSSPVTGSVAPVHHTPWEKAMDDSMKTFL

3D structure

• PDB: 7d4k Structural and Mechanistic Insights Into Dimethylsulfoxide Formation Through Dimethylsulfide Oxidation.
• Chain: B
• Resolution: 1.8 Å

Enzymatic activity

• Enzyme Commision number: 1.14.13.148: trimethylamine monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	B	Y66 W70 N72 F162 P168 Y170 S202 S203 Y204 S205 D208 R226 H227 C268 T269	Y65 W69 N71 F161 P167 Y169 S201 S202 Y203 S204 D207 R225 H226 C267 T268
BS02	FAD	B	I7 G8 G10 P11 C12 E37 K38 Q39 G44 L45 W46 S71 N72 R124 V125 T159 F162 F277 Q315 T318	I6 G7 G9 P10 C11 E36 K37 Q38 G43 L44 W45 S70 N71 R123 V124 T158 F161 F276 Q314 T317

Gene Ontology

Molecular Function

• GO:0004497 monooxygenase activity
• GO:0004499 N,N-dimethylaniline monooxygenase activity
• GO:0050660 flavin adenine dinucleotide binding
• GO:0050661 NADP binding

External links

• PDB: RCSB:7d4k, PDBe:7d4k, PDBj:7d4k
• PDBsum: 7d4k
• PubMed: 34630359
• UniProt: B6BQB2|TMM_PELS7 Trimethylamine monooxygenase (Gene Name=tmm)